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Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing

Stephens AD, Nespovitaya N, Zacharopoulou M, et al. "Different Structural Conformers of Monomeric α-Synuclein Identified after Lyophilizing and Freezing." Anal. Chem. (2018), 90(11):6975–6983 Abstract Understanding the mechanisms behind amyloid protein aggregation in diseases, such as Parkinson’s...

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Computer-aided discovery of a metal–organic framework with superior oxygen uptake

Moghadam PZ, Islamoglu T, Goswami S, et al. "Computer-aided discovery of a metal-organic framework with superior oxygen uptake." Nat. Commun. (2018), 9(1) pdf Abstract Current advances in materials science have resulted in the rapid emergence of thousands of functional adsorbent materials in recent...

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Flat-Field Super-Resolution Localization Microscopy with a Low-Cost Refractive Beam-Shaping Element.

Rowlands CJ, Ströhl F, Ramirez PPV, Scherer KM & Kaminski CF. "Flat-Field Super-Resolution Localization Microscopy with a Low-Cost Refractive Beam-Shaping Element." Sci. Rep (2018), 8(1):5630. Abstract Super-resolution single-molecule localization microscopy, often referred to as PALM/STORM...

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Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly

Boott CE, Leitao EM, Hayward DW, et al. "Probing the Growth Kinetics for the Formation of Uniform 1D Block Copolymer Nanoparticles by Living Crystallization-Driven Self-Assembly." ACS Nano . (2018), 12(9):8920–8933. Abstract Living crystallization-driven self-assembly (CDSA) is a seeded growth...

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Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly

Lu M, Banetta L, Young LJ, et al. " Live-cell super-resolution microscopy reveals a primary role for diffusion in polyglutamine-driven aggresome assembly." J. Biol. Chem. (2018), jbc-RA118.003500 Abstract The mechanisms leading to self-assembly of misfolded proteins into amyloid aggregates have...

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Structured illumination microscopy with extended axial resolution through mirrored illumination

Manton JD, Ströhl F, Fiolka R, Kaminski CF, Rees EJ. "Structured illumination microscopy with extended axial resolution through mirrored illumination." arXiv Preprint . (2018) arXiv1810.04590 Abstract Wide-field fluorescence microscopy, while much faster than confocal microscopy, suffers from a...

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Structural progression of amyloid- Arctic mutant aggregation in cells revealed by multiparametric imaging

Lu M, Williamson N, Mishra A, et al. "Structural progression of amyloid-β Arctic mutant aggregation in cells revealed by multi-parametric imaging." J. Biol. Chem. (2018), jbc-RA118RA118.004511. Abstract The 42-amino-acid β-amyloid (A42) is a critical causative agent in the pathology of Alzheimer’s...

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Single particle trajectories reveal active endoplasmic reticulum luminal flow

Holcman D, Parutto P, Chambers JE, et al. "Single particle trajectories reveal active endoplasmic reticulum luminal flow. " Nat. Cell Biol. (2018), 20(10):1118. Abstract The endoplasmic reticulum (ER), a network of membranous sheets and pipes, supports functions encompassing biogenesis of secretory...

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FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-p Interactions

S Qamar, GZ Wang, SJ Randle, et al. "FUS Phase Separation Is Modulated by a Molecular Chaperone and Methylation of Arginine Cation-π Interactions." Cell . (2018), 173(3):720–734. Abstract Reversible phase separation underpins the role of FUS in ribonucleoprotein granules and other membrane-free...

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Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure

Laine RF, Goodfellow G , Young LJ, Travers J, Carroll D, Dibben O, Bright H & Kaminski CF. "Structured illumination microscopy combined with machine learning enables the high throughput analysis and classification of virus structure." eLife (2018), 7. Abstract Optical super-resolution...

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