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Research

The central theme of our work is the development and application of modern laser spectroscopy and imaging methods to elucidate details and dynamics of chemical processes. Below you find summaries of, and links to, key research projects currently going on in the group.

Molecular Mechanisms of disease

We use a range of advanced biological and biophysical methods to probe the molecular chemistry of disease in live cells and in animal models.  Currently a major focus is on the study of protein misfolding and aggregation in neurodegeneration. 

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Microscopy Development

We perform both experimental and theoretical work to optimize speed, resolution, and sensitivity for applications ranging from single molecule biophysics to whole organism imaging.

SPIM microscope for live embryo imaging

Molecular Sensing

We model and generate supercontinuum radiation in optical fibres for applications in chemical sensing using instruments that are optimized for sensitivity and speed.

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Building bespoke high-resolution imaging platforms for research into neurodegeneration.

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Single molecule translation imaging

Nov 15, 2017

Single molecule translation imaging, SMTI, is a novel technique development by the Laser Analytics group to measure the rate and spatial distribution of protein synthesis [1,2]. Together with scientists form the Department of Physiology and Development of the University of Cambridge, we study the processes underlying neurodevelopment and the formation of neuronal networks in vivo.

The LAG offers best wishes to Dr. Romain Laine on his next adventure

Oct 30, 2017

The LAG says farewell to Dr. Romain Laine as he moves to his new position as a research fellow in Ricardo Henriques' lab at University College London.

LAG and MNG members participate in the 2017 Chariots of Fire relay race

Sep 18, 2017

Laser Analytics Group members Nathan Curry and Pedro Vallejo Ramirez, along with Molecular Neuroscience Group members Amberley Stephens, Nadya Nespovitaya, Ajay Mishra, and Miranda Robbins participated in the annual Chariots of Fire relay race.

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