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Molecular Sensing

The generation of broad bandwidth supercontinuum generation is central to much of our research in molecular spectroscopy and imaging.  For an overview of methods we use see [1].  Previously we performed a lot of molecular imaging in reactive gas flows, an area we are less involved in now. If you are interested in this work, please refer to this link.  Current projects are:

High sensitivity spectroscopy with supercontinuum radiation

We have pioneered the use of incoherent supercontinuum radiation in ultrahigh sensitivity cavity enhanced absorption spectroscopy (CEAS). In the gas phase we have reached record sensitivities for broad bandwidth CEAS, closely approaching those of single frequency or frequency comb absorption spectroscopies, but offering speed advantages and much reduced experimental complexity. More details can be found here and in [2].  We have expanded these methods for measurements in the liquid phase [3] and for the probing of electrochemical reactions [4] and have recently developed broad band cavity ringdown spectroscopy (CRDS) with supercontinuum sources using novel single photon avalanche photo diode (SPAD) detector arrays [5].  Applications for these technique range from the biophysical study of amyloid aggregation reactions to atmospheric chemistry.

Wavelength agile sensing

Through temporal dispersion of different wavelength components in supercontinuum it is possible to perform ultra high speed wavelength sweeps, permitting spectra capturing hundreds of nanometers at 100s of kHz repetition rates.  This permits the simultaneous detection of multiple gas species, e.g. H20 and CHe.g. for the study of fast chemical kinetics in flows.  For details see here and [6] [7].

Modelling Supercontinuum Radiation for spectroscopy applications

The group performs extensive theoretical work on incoherent supercontinuum generation in photonic crystal fibres to optimize its use for spectroscopy. Algorithms developed in the group to solve the  non-linear Schrödinger equation have become a standard method for modeling this process, for details see [6]. We have used this to study soliton generated noise and optical rogue waves [7] [8]. 

Stable Calibration Burner

The laser analytics group has developed a novel flat flame calibration burner that supports stable laminar flames and combines many of the advantages of several widely used burner designs without their disadvantages. It permits the application of point measurement techniques, line-of-sight techniques and planar imaging techniques with the advantage that trace species, such as metal atoms, can be easily introduced into the flame. The purpose of the burner is to provide an accurate means for calibrating and validating other laser based thermometry and absorption techniques. We have completely characterised this flame and set up a database, which can be used by other researchers for reference. We have used coherent anti-Stokes Raman scattering (CARS) to obtain accurate temperature profiles in this flame over a range of operating conditions. Although experimentally complex, CARS still serves as a "gold standard" for other laser based measurements as it combines excellent accuracy and precision with a high spatial resolution. We have pushed CARS to its limits in terms of measurement fidelity and its application in the calibration of our burner describes some of the most precise and accurate measurements ever reported with this technique [9]. Design Files

FlatFlame


[1] Kaminski CF et al., "Supercontinuum radiation for applications in chemical sensing and microscopy" (2008)
[2] Langridge JM et al., "Cavity enhanced absorption spectroscopy of multiple trace gas species using a supercontinuum radiation source" (2008)
[3]  Kiwanuka SS et al., "Sensitive Method for the Kinetic Measurement of Trace Species in Liquids Using Cavity Enhanced Absorption Spectroscopy with Broad Bandwidth Supercontinuum Radiation" (2010)
[4] Schnippering M et al., "Evanescent Wave Broadband Cavity Enhanced Absorption Spectroscopy using Supercontinuum Radiation: A New Probe of Electrochemical Processes"  (2008)
[5] Kiwanuka SS et al., "Development of broadband cavity ring-down spectroscopy for biomedical diagnostics of liquid analytes" (2012)
[6] Hult J et al., "High bandwidth absorption spectroscopy with a dispersed supercontinuum source" (2007)
[7] Hult J et al., "Dispersion measurement in optical fibers using supercontinuum pulses" (2007)
[8] Liu C et al., "Predicting supercontinuum pulse collisions with simulations exhibiting temporal aliasing" (2010) 
[9] Hartung G et al., "A flat flame burner for the calibration of laser thermometry techniques" (2006)

Building bespoke high-resolution imaging platforms for research into neurodegeneration.

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Single molecule translation imaging

Nov 15, 2017

Single molecule translation imaging, SMTI, is a novel technique development by the Laser Analytics group to measure the rate and spatial distribution of protein synthesis [1,2]. Together with scientists form the Department of Physiology and Development of the University of Cambridge, we study the processes underlying neurodevelopment and the formation of neuronal networks in vivo.

The LAG offers best wishes to Dr. Romain Laine on his next adventure

Oct 30, 2017

The LAG says farewell to Dr. Romain Laine as he moves to his new position as a research fellow in Ricardo Henriques' lab at University College London.

LAG and MNG members participate in the 2017 Chariots of Fire relay race

Sep 18, 2017

Laser Analytics Group members Nathan Curry and Pedro Vallejo Ramirez, along with Molecular Neuroscience Group members Amberley Stephens, Nadya Nespovitaya, Ajay Mishra, and Miranda Robbins participated in the annual Chariots of Fire relay race.

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