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Post Doctoral Research Associate/Assistant

Department of Chemical Engineering and Biotechnology

A post-doctoral Research Assistant/Associate position is available.  The post holder will be responsible to build up a state of the art imaging laboratory at the Cambridge UK DRI Centre,  and work between the groups of Prof Clemens Kaminski (Department of Chemical Engineering and Biotechnology) and Prof Giovanna Mallucci (Clinical Neurosciences and Director of the Cambridge DRI).  In particular, the candidate will build up bespoke high-resolution imaging platforms for research into neurodegeneration. The post holder will set up a state-of-the-art platform for single molecule super-resolution imaging and particle tracking and high speed structured illumination imaging and manage research activities in the new lab.  The post holder will conduct experiments to quantify the local synthesis of key synaptic proteins in live neurons (see Stroehl et al, Scientific Reports, 2017 and Wong et al, Neuron, 2017), and correlate these measurements with the development of synaptic topology and nerve circuitry.  The programme will then investigate the effect of cold shock proteins on regeneration of neurones and synaptic plasticity.

Candidates should have a PhD (or equivalent experience) in a relevant discipline. (Biophotonics, Cell biology, Biophysics, etc.). Where the successful applicant does not yet have a PhD, he/she will normally be under-appointed as a Research Assistant on the understanding that he/she will be appointed as a Research Associate upon successful completion of his/her PhD).

Candidates should have experience in the development and application of advanced microscopy techniques is essential.  Knowledge in single molecule localisation and structured illumination imaging techniques would be an advantage. Skills in hardware control (Labview) and image processing (Matlab) are highly desirable, along with prior experience in biological imaging.

Candidates should have excellent interpersonal and communication skills.  The post comes with considerable leadership responsibilities.  The holder will lead a small team of researchers, oversee a research programme, and operate in a highly interdisciplinary environment involving cell biologists, biochemists, and medics.

Experience of Fluorescence microscopy in the neuroscience; development of original imaging modalities would also be an advantage.

Fixed-term: The funds for this post are available for 36 months in the first instance.

Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment. 

The SMTI procedure in xenopus embyos. (a) A fusion construct between a protein of interest and the YFP Venus is (b) introduced into retinal ganglion cell. (c) The cells are dissected and cultured in a dish to study the effect of various chemicals, so-called guidance cues, on local translation in axon tips. (d) This is quantified via the SMTI procedure: segmentation, bleaching, and localisation. (e) Changes can be measured upon cue application even during SMTI acquisitions.

The SMTI procedure in xenopus embyos. (a) A fusion construct between a protein of interest and the YFP Venus is (b) introduced into retinal ganglion cell. (c) The cells are dissected and cultured in a dish to study the effect of various chemicals, so-called guidance cues, on local translation in axon tips. (d) This is quantified via the SMTI procedure: segmentation, bleaching, and localisation. (e) Changes can be measured upon cue application even during SMTI acquisitions. Image provided by Florian Stroehl. 

Professor Thomas Huser will be giving a talk to the group on January 22 at 2:00 PM in CEB. He will present his latest efforts in unveiling and following structural changes of cellular nanopores in living cells by GPU-enhanced super-resolution structured illumination microscopy.

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