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Chetan Poudel

Chetan Poudel

Supercontinuum Radiation for the Development of Automated Microscopy Platforms

Laser Analytics Group

SUPUVIR ITN


Office Phone: +44 (0)1223 762924

Biography:

B.A. in Physics - Oberlin College, 2014
Imaging in Diabetes Research Assistant - University of Wisconsin-Madison, 2014-16
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In the Laser Analytics Group, I am working primarily on an automated, drug-screening microscopy platform, based on time-gated FLIM and supercontinuum lasers. I am interested in the applications of this technique to study neurodegeneration in live C. elegans worms, to investigate nuclear condensation and to design drug-screening assays. 

Keywords

  • Neurodegeneration
  • Microscopy
  • Bioimaging

Equipment

  • Lifetime and Spectral Imaging

Key Publications

a. Using fluorescence lifetime imaging (FLIM) for metabolic imaging in the field of diabetes and aging: 
Gregg, T.A.*, Poudel, C.*, Schmidt, B.A., Dhillon, R.S., Sdao, S.M., Truchan, N.A., Baar, E.L., Fernandez, L.A., Denu, J.M., Eliceiri, K.W., Rogers, J.D., Kimple, M.E., Lamming, D.W., and Merrins, M.J. (2016) ’Pancreatic Beta cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity.’ Diabetes, 2016 June.
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b. Simultaneous patch-clamp electrophysiology with FRET measurements and calcium imaging:  
Merrins, M.J., Poudel, C., McKenna, J.P., Ha, J., Sherman, A., Bertram, R. and Satin, L.S. (2016) ’Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet Beta Cells’, Biophysical Journal, vol.110, Issue 3, pp.691-699. 
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c. Separation of magnetic nanoparticles using a custom-built magnet array:

Ijiri, Y., Poudel, C., Williams,P., Moore, L., Orita, T. and Zborowski, M. (2013) 'Inverted Linear Halbach Array for Separation of Magnetic Nanoparticles’, IEEE Transactions on Magnetics, vol. 49, no. 7, pp. 3449-3452.