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Chetan Poudel

Chetan Poudel

Supercontinuum Radiation for the Development of Automated Microscopy Platforms

Laser Analytics Group

SUPUVIR ITN


Office Phone: +44 (0)1223 762924

Biography:

B.A. in Physics - Oberlin College, 2014
Imaging in Diabetes Research Assistant - University of Wisconsin-Madison, 2014-16
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In the Laser Analytics Group, I am working primarily on an automated, drug-screening microscopy platform, based on time-gated FLIM and incorporating supercontinuum excitation. I am interested in applying this technique to study neuro-degeneration in live C. elegans worms, to investigate chromatin condensation and to design drug-screening assays. 

Key Publications

a. Using fluorescence lifetime imaging (FLIM) for metabolic imaging in the field of diabetes and aging: 
Gregg T.A.*, Poudel C.*, Schmidt B.A., Dhillon R.S., Sdao S.M., Truchan N.A., Baar E.L., Fernandez L.A., Denu J.M., Eliceiri K.W., Rogers J.D., Kimple M.E., Lamming D.W., and Merrins M.J. (2016) ’Pancreatic Beta cells from Mice Offset Age-Associated Mitochondrial Deficiency with Reduced KATP Channel Activity.’ Diabetes, 2016 June.
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b. Simultaneous patch-clamp electrophysiology with FRET measurements and calcium imaging:  
Merrins M.J., Poudel C., McKenna J.P., Ha J., Sherman A., Bertram R. and Satin L.S. (2016) ’Phase Analysis of Metabolic Oscillations and Membrane Potential in Pancreatic Islet Beta Cells’, Biophysical Journal, vol.110, Issue 3, pp.691-699. 
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c. Imaging of metabolic health of pancreatic islets:
Cummings N.E., Williams E.M., Kasza I., Konon E.N., Schaid M.D., Schmidt B.A., Poudel C., Sherman D.S., Yu D., Arriola Apelo S.I., Cottrell S.E., Geiger G., Barnes M.E., Wisinski J.A., Fenske R.J., Matkowskyj K.A., Kimple M.E., Alexander C.M., Merrins M.J., Lamming D.W. (2017) 'Restoration of Metabolic Health by decreased consumption of branched-chain amino acids', Journal of Physiologydoi: 10.1113/JP275075.
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d. Separation of magnetic nanoparticles using a custom-built magnet array:

Ijiri, Y., Poudel, C., Williams,P., Moore, L., Orita, T. and Zborowski, M. (2013) 'Inverted Linear Halbach Array for Separation of Magnetic Nanoparticles’, IEEE Transactions on Magnetics, vol. 49, no. 7, pp. 3449-3452.