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Nobel prize awarded for optical super-resolution microscopy

last modified Feb 17, 2015 09:10 PM
The inventors of single molecule localisation and stimulated emission depletion (STED) super-resolution microscopy were today honoured with the Nobel prize for chemistry. One of the key applications of super-resolution imaging, pioneered by the Laser Analytics Group and mentioned by the Nobel Assembly, is the study of protein aggregation reactions in the context of neurodegenerative diseases.

Super-resolution fluorescence microscopy (or nanoscopy) is a key enabler for research conducted by the Laser Analytics Group and we were thrilled to hear today that the inventors of optical nanoscopy have been honoured with the Nobel Prize.

In what has become known as nanoscopy, scientists visualise the pathways of individual molecules inside living cells.

They can see how molecules create synapses between nerve cells in the brain; they can track proteins involved in Parkinson’s, Alzheimer’s and Huntington’s diseases as they aggregate.

The Nobel Assembly discuss work pioneered by the group whilst announcing the award

For more information about super-resolution microscopy and how this is being applied to the study of the molecular mechanism of disease please see our recent feature on this website, that explains in more detail the activities in superresolution microscopy developments in the group.

The Laser Analytics Group  congratulates Dr. Betzig, Professor Hell and Professor Moerner on their outstanding achievements.

Relevant publications

Kaminski Schierle GS, van de Linde S, Erdelyi M, Esbjörner EK, Klein T, Rees E, Bertoncini CW, Dobson CM, Sauer M, and Kaminski CF, "In Situ Measurements of the Formation and Morphology of Intracellular ß-Amyloid Fibrils by Super-Resolution Fluorescence Imaging", J. Am. Chem. Soc., 133 (33), pp 12902–12905, (2011). DOI | pdf | summary

Michel CH, Kumar S, Pinotsi D, Tunnacliffe A, St George-Hyslop P, Mandelkow E, Mandelkow E-M, Kaminski CF, Kaminski Schierle GS, "Extracellular Monomeric Tau is Sufficient to Initiate the Spread of Tau Pathology", J. Biol. Chem. (2014), 289: 956-967. DOI | pdf | summary

Pinotsi D, Büll AK, Galvagnion C, Dobson CM, Kaminski-Schierle GS, Kaminski CF, "Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy," Nano Letters (2013), 14 (1), 339–345 DOI | pdf | summary

Fritschi S K, Langer F, Kaeser S A, Maia L F, Portelius E, Pinotsi D, Kaminski C F, Winkler D T, Maetzler W, Keyvani K, Spitzer P, Wiltfang J, Kaminski Schierle G S, Zetterberg H, Staufenbiel M, Jucker M, "Highly potent soluble amyloid-β seeds in human Alzheimer brain but not cerebrospinal fluid," Brain (2014). awu255. DOI | pdf | summary

Esbjörner E K, Chan F, Rees EJ, Erdelyi M, Luheshi LM, Bertoncini CW, Kaminski CF, Dobson CM, Kaminski-Schierle GS, "Direct Observations of the Formation of Amyloid β Self-Assembly in Live Cells Provide Insights into Differences in the Kinetics of Aβ(1–40) and Aβ(1–42) Aggregation," Chemistry and Biology (2014)  DOI |pdf | summary

Kaminski C F, Pinotsi D, Michel C H, Kaminski Schierle G S, "Nanoscale imaging of neurotoxic proteins", SPIE NanoScience+ Engineering (2013), 91690N--91690N. DOI | pdf | summary

Further information on superresolution techniques available in the group