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Research

The central theme of our work is the development and application of modern laser spectroscopy and imaging methods to elucidate details and dynamics of chemical processes. Below you find summaries of, and links to, key research projects currently going on in the group.

Molecular Mechanisms of disease

We use a range of advanced biological and biophysical methods to probe the molecular chemistry of disease in live cells and in animal models.  Currently a major focus is on the study of protein misfolding and aggregation in neurodegeneration. 

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Microscopy Development

We perform both experimental and theoretical work to optimize speed, resolution, and sensitivity for applications ranging from single molecule biophysics to whole organism imaging.

SPIM microscope for live embryo imaging

Molecular Sensing

We model and generate supercontinuum radiation in optical fibres for applications in chemical sensing using instruments that are optimized for sensitivity and speed.

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Professor Thomas Huser will be giving a talk to the group on January 22 at 2:00 PM in CEB. He will present his latest efforts in unveiling and following structural changes of cellular nanopores in living cells by GPU-enhanced super-resolution structured illumination microscopy.

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LAG member wins department video competition

Jan 14, 2018

LAG member Marcus Fantham won the Chemical Engineering and Biotechnology department video competition in December with a short clip featuring the work inside the group.

The LAG, MNG, and QI have their annual Christmas Dinner

Dec 08, 2017

The LAG, MNG, and QI get together to celebrate the holidays at Murray Edwards College.

Single molecule translation imaging

Nov 15, 2017

Single molecule translation imaging, SMTI, is a novel technique development by the Laser Analytics group to measure the rate and spatial distribution of protein synthesis [1,2]. Together with scientists form the Department of Physiology and Development of the University of Cambridge, we study the processes underlying neurodevelopment and the formation of neuronal networks in vivo.

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