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Post Doctoral Research Position

STED microscopy development for research into molecular mechanisms of disease

Superresolution imaging of polyglutamine aggresomes in neurones, credit Meng Lu

Superresolution imaging of polyglutamine aggresomes in neurones, credit Meng Lu

Salary: £28,695-£37,394

We are looking for a motivated PDRA to be in charge of the recently developed STED super-resolution microscope in the Laser Analytics Group, Department of Chemical Engineering and Biotechnology (http://laser.ceb.cam.ac.uk). The system has state-of-the-art capabilities through adaptive optics and time gated detection and routinely achieves 35 nm resolution. Additionally, it incorporates an Atomic Force Microscopy platform for correlative imaging by STED and AFM in situ.

The research programme will require the further development of the current STED microscope to permit simultaneous two-colour imaging, and the development of STED-FCS (Fluorescence correlation spectroscopy). The instrument will be used in projects to research aspects of neurodegeneration.  In particular we will study the kinetics of protein aggregation reactions in vitro, in cell culture models of disease, and in brain tissue in the context of Alzheimer’s disease. The programme will be in close collaboration with the Neurodegenerative disease consortium in Cambridge (https://www.youtube.com/watch?v=W-0GWbOFT3w ) and is closely connected to the Cambridge Advanced Imaging Centre (CAIC) Initiative.

The candidate will have a PhD in Physics, Engineering, Biophysics, or a similar discipline with a proven track record in optical microscopy development and application, ideally with experience in STED or other super-resolution methods, and with ample knowledge in optical system development. Good skills in LabView and MATLAB are highly advantageous for the position. Skills in a biological discipline, for example sample preparation and labelling, would be highly advantageous. The candidate has to have a strong interest to cross over into the biological sciences. 

The STED microscope is used in collaboration within a number of biological projects from across the University of Cambridge, so there is excellent opportunity for scientific outputs in high impact journals.

 The post is for limited to 2 years in the first instance and is available immediately.

 For enquiries please contact Prof. Clemens Kaminski,

Building bespoke high-resolution imaging platforms for research into neurodegeneration.

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