Laser Analytics Group
Herpesvirus assembly and egress
Biography:
I am a Research Associate in the group of Clemens Kaminski at the University of Cambridge where I work on virus-host cell interaction using advanced fluorescence imaging methods. Previously, I was awarded an individual fellowship by the German Research Foundation and investigated the dynamics of herpesvirus assembly and egress and related changes in host-cell morphology.
Before coming to Cambridge in March 2017, I was a postdoc in Tom Shimizu’s lab at the AMOLF institute in Amsterdam studying the organisation of chemotaxis receptors in E. coli. Previously, I completed my PhD in Chemistry under the supervision of Ulrich Kubitscheck at the University of Bonn, where I investigated the mechanisms of the action of antibiotics.
Key Publications
K. M. Scherer, J. D. Manton, T. Soh, L. Mascheroni, C. M. Crump, C. F. Kaminski, Temporal analysis of organelle and cytoskeleton reorganisation during herpesvirus infection, in preparation.
F. Grein*, A. Müller*, K. M. Scherer*, X. Liu, K. Ludwig, A. Klöckner, M. Strach, H.-G. Sahl, U. Kubitscheck, T. Schneider, Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids, under review.
C. J. Rowlands, F. Stroehl, P. P. V. Ramirez, K. M. Scherer, C. F. Kaminski, Flat-field super-resolution localization microscopy with a low-cost refractive beam-shaping element, Sci. Rep. 2018, 8:5630.
J. Solari, F. Anquez, K. M. Scherer, T. S. Shimizu, Bacterial chemoreceptor imaging at high spatiotemporal resolution using photoconvertible fluorescent proteins, Methods Mol Biol. 2018, 1729, 203-231.
K. M. Scherer, J.-H. Spille, F. Grein, H.-G. Sahl, U. Kubitscheck, The lantibiotic nisin induces formation of large Lipid II aggregates causing membrane instability and vesicle budding, Biophys. J. 2015, 108, 1114-1124.
J.-H. Spille, T. Kaminski, K. Scherer, J. S. Rinne, A. Heckel, U. Kubitscheck, Extended, sensitive and fast 3D-tracking of single molecules and RNA particles in living tissue, Nucleic Acids Res. 2014, pii: gku1194.
K. Scherer, I. Wiedemann, C. Ciobanasu, H.-G. Sahl, U. Kubitscheck, Aggregates of nisin with various bactoprenol-containing cell wall precursors differ in size and membrane permeation capacity, Biochim. Biophys. Acta 2013, 1828, 2628-2636.