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Herpesvirus assembly and egress


I am a Research Associate in the group of Clemens Kaminski at the University of Cambridge where I work on virus-host cell interaction using advanced fluorescence imaging methods. Previously, I was awarded an individual fellowship by the German Research Foundation and investigated the dynamics of herpesvirus assembly and egress and related changes in host-cell morphology.

Before coming to Cambridge in March 2017, I was a postdoc in Tom Shimizu’s lab at the AMOLF institute in Amsterdam studying the organisation of chemotaxis receptors in E. coli. Previously, I completed my PhD in Chemistry under the supervision of Ulrich Kubitscheck at the University of Bonn, where I investigated the mechanisms of the action of antibiotics.



Key publications: 

Luca Mascheroni*, Katharina M. Scherer*, Edward Ward, Oliver Dibben, Clemens F. Kaminski, Combining light sheet microscopy and expansion microscopy for fast 3D imaging of virus-infected cells with super-resolution, bioRxiv 2020.

K. M. Scherer, J. D. Manton, T. Soh, L. Mascheroni, C. M. Crump, C. F. Kaminski, Temporal analysis of organelle and cytoskeleton reorganisation during herpesvirus infection, .

F. Grein*, A. Müller*, K. M. Scherer*, X. Liu, K. Ludwig, A. Klöckner, M. Strach, H.-G. Sahl, U. Kubitscheck, T. Schneider, Ca2+-Daptomycin targets cell wall biosynthesis by forming a tripartite complex with undecaprenyl-coupled intermediates and membrane lipids, Nature Communications 2020, 11, 1455.

C. J. Rowlands, F. Stroehl, P. P. V. Ramirez, K. M. Scherer, C. F. Kaminski, Flat-field super-resolution localization microscopy with a low-cost refractive beam-shaping element, Sci. Rep. 2018, 8:5630.

J. Solari, F. Anquez, K. M. Scherer, T. S. Shimizu, Bacterial chemoreceptor imaging at high spatiotemporal resolution using photoconvertible fluorescent proteins, Methods Mol Biol. 2018, 1729, 203-231.

K. M. Scherer, J.-H. Spille, F. Grein, H.-G. Sahl, U. Kubitscheck, The lantibiotic nisin induces formation of large Lipid II aggregates causing membrane instability and vesicle budding, Biophys. J. 2015, 108, 1114-1124.

J.-H. Spille, T. Kaminski, K. Scherer, J. S. Rinne, A. Heckel, U. Kubitscheck, Extended, sensitive and fast 3D-tracking of single molecules and RNA particles in living tissue, Nucleic Acids Res. 2014, pii: gku1194.

K. Scherer, I. Wiedemann, C. Ciobanasu, H.-G. Sahl, U. Kubitscheck, Aggregates of nisin with various bactoprenol-containing cell wall precursors differ in size and membrane permeation capacity, Biochim. Biophys. Acta 2013, 1828, 2628-2636.

Laser Analytics Group
Dr Katharina  Scherer

Contact Details

+44 (0)1223 762924
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