Biography
I am a Research Associate in Biophotonics in the Laser Analytics Group headed by Prof Clemens Kaminski, working on developing and using optical microscopy tools for brain organoid imaging and other applications.
Previously in the Photonics Group at Imperial College London, I worked on the development and application of dual-view oblique plane microscopy (dOPM), a single-objective light-sheet fluorescence microscopy technique, for cleared tissue imaging and heterogenous 3D cancer spheroid models. My PhD work in the lab of Prof Chris Dunsby work was focused on remote-refocusing light-sheet fluorescence microscopy, applied to high-speed volumetric imaging of calcium dynamics in cardiomyocytes.
Prior to that, I completed a BSc in Physics, followed by a MSc in Optics and Photonics and MRes in Chemical Biology at Imperial College London. My research interests are focused on the development and application of novel optical instrumentation concepts for fast, high-resolution 3D biomedical imaging.
Publications
Dvinskikh L, Sparks H, MacLeod KT and Dunsby C. High-speed 2D light-sheet fluorescence microscopy enables quantification of spatially varying calcium dynamics in ventricular cardiomyocytes. Front. Physiol. Sec. Cardiac Electrophysiology Vol 14:
DOI: 10.3389/fphys.2023.1079727
Dvinskikh L, Sparks H, Brito L, Harding S, MacLeod K, Dunsby C. Remote-refocusing light-sheet fluorescence microscopy enables 3D imaging of electromechanical coupling of hiPSC-derived and adult cardiomyocytes in co-culture Scientific Reports, Guest Edited Collection: “Imaging of cells and cellular dynamics”, Vol. 13, DOI: 10.1038/s41598-023-29419-w
Hong W, Wright T, Sparks H, Dvinskikh L, MacLeod K, Paterson C, Dunsby C. Adaptive Light-Sheet Fluorescence Microscopy with a Deformable Mirror for Video-Rate Volumetric Imaging, Applied Physics Letters, “Advances in Optical Microscopy for Bioimaging” Special topic, 121, 193703. DOI: 10.1063/5.0125946
Sparks H, Dvinskikh L, Firth J, Francis A, Harding S, Paterson C, MacLeod K, Dunsby C. Development of a flexible light-sheet fluorescence microscope for high-speed 3D imaging of calcium dynamics and 3D imaging of cellular microstructure, Journal of Biophotonics, Vol 13, Issue 6. DOI: 10.1002/jbio.201960239
